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Moreover, the availability of multiple effective obesity pharmacotherapies with different mechanisms of action will provide clinicians the opportunity to select treatments based on patient preference, underlying comorbidities, medication safety profile and treatment response, with an aim to achieve the individualised WL targets, improve the overall health and/or the quality of life [7]

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Back then, the company basked in the glow of orforglipron becoming the first oral GLP-1 drug to ace a Phase III trial when it reported results from ACHIEVE-1 (NCT05971940) showing that orforglipron met the trials primary endpoint of superior A1C reduction vs

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Effect of long-acting liraglutide QD on HR A 24-h time-averaged increase in mean placebo- and baseline-adjusted HR of 78 bpm was reported following liraglutide 1.2 and 1.8 mg QD (titrated in 0.6-mg weekly steps) using serial ECG monitoring at the end of the second and third weeks (after the seventh and final dose) of liraglutide (N = 51)